P196 - THE IMPACT OF INFLAMMATORY BOWEL DISEASE SEVERITY ON HEALTH-RELATED QUALITY OF LIFE
(Room Poster Hall)
19 Jan 18
5:30 PM
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7:00 PM
Tracks:
Management of Complicated IBD
Background: Few studies have examined the association between severity of inflammatory bowel disease (IBD) and humanistic burden. The current study examined the association between IBD severity and health-related quality of life (HRQoL). Methods: Data from the 2015 US National Health and Wellness Survey (N=97,700) were used to identify IBD patients, defined as those who self-reported a diagnosis of Crohn’s disease or ulcerative colitis. Respondents with IBD (n=1,020) were categorized by self-reported IBD severity: mild (n=620), moderate (n=307), and severe (n=93). Comparisons were made across IBD severity groups and a non-IBD matched control group (n=1,020); the latter identified using propensity score matching (1:1 ratio). HRQoL was assessed with SF-36v2 metrics: Mental Component Summary (MCS), Physical Component Summary (PCS), Health State Utilities Score (SF-6D), and health domain scores. Post-match, one-way omnibus ANOVAs examined whether HRQoL differed by IBD status and severity. Results: There was a linear trend across severity cohorts: as severity increased, HRQoL decreased. Matched controls without IBD had the highest MCS and PCS scores (Means [M]=47.8; 48.4), followed by those with mild (M=45.6; 45.7), moderate (M=39.9; 39.9), and severe IBD (M=40.2; 38.7) (p<0.001). Similarly, non-IBD matched controls had the highest SF-6D scores (M=0.71), followed by those with mild (M=0.68), moderate (M=0.59), and severe IBD (M=0.58) (p<0.001). Differences on all HRQoL outcomes between those with moderate/severe IBD compared with mild IBD and non-IBD controls exceeded minimally important differences. Conclusion: As IBD severity increases, so does the HRQoL burden on IBD patients. Findings suggest that reducing IBD severity to even a mild level may potentially improve health-related quality of life among individuals with IBD.