P137 - CLINICAL FACTORS RELATED TO LOW BONE MINERAL DENSITY IN NEWLY DIAGNOSED PATIENTS WITH INFLAMMATORY BOWEL DISEASE
(Room Poster Hall)
19 Jan 18
5:30 PM
-
7:00 PM
Tracks:
Defining Optimal Treatment Algorithms
Introduction Many factors about low bone mineral density (BMD) in patients with inflammatory bowel disease (IBD) have been reported. Background However, prevalence and risk factors of low BMD in newly diagnosed patients with ulcerative colitis (UC) and Crohn’s disease (CD) have not been suggested. Aims Therefore, we aimed to examine the prevalence of low BMD in each disease entity and analyzed the clinical factors associated with low BMD in initially diagnosed patients with UC and CD. Methods We performed a prospective study, from 6 tertiary referral center in Daegu Korea, between November 2014 and April 2017. Totally 132 patients age under 50 were enrolled. 68 patients were newly diagnosed UC and 64 patients were newly diagnosed CD, respectively. BMD was calculated with dual-energy X-ray absorptiometry, and then we obtained Z score to evaluate BMD with adjusted age. We examined the prevalence of low BMD in UC and CD patients. And then, we categorized two groups, one is normal BMD (Z score > -1) and the other is reduced BMD (Z score ≤-1). From these results, we analyzed clinical factors related to low BMD in initially diagnosed UC and CD patients. Results Of 68 patients with UC, 46 (67.6%) had normal BMD and 22 (32.4%) had reduced BMD. Also, of 64 patients with CD, 40 (62.5%) presented normal BMD and 24 (37.5%) presented reduced BMD, as assessed by Z score. Multivariate analysis suggested that risk factors for low BMD were a high level of alkaline phosphatase (ALP) (more than 140 U/L) (HR 15.615; 95% CI 1.547 - 157.617; p= 0.020) in UC, and underweight (BMI under 18.5 Kg/M2) (HR 0.254; 95% CI 0.082 - 0.791; p= 0.018) in CD. Conclusions Our study reports that low BMD is a common trait in IBD. The clinical factors associated with low BMD in UC is a high level of ALP. That of CD is underweight. Therefore, evaluation of BMD should be performed in newly diagnosed IBD patients, especially when the patients accompany with a high level of ALP and underweight.