P018 - CLINICAL COURSE AND OUTCOMES OF INFLAMMATORY BOWEL DISEASE PATIENTS WHO UNDERWENT SOLID ORGAN TRANSPLANTATION IN KOREA
(Room Poster Hall)
19 Jan 18
5:30 PM
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7:00 PM
Tracks:
Clinical and Research Challenges
Background and Aims: According to the previous researches, there are variable results after solid organ transplantation (SOT) in inflammatory bowel disease (IBD) patients. However, no published data has been found in Asia. We aim to analyze the clinical course and outcomes of IBD patients who underwent SOT in Korea. Methods: We investigated 7030 IBD patients and discovered 22 IBD patients who had SOT between 1989 and 2017. Analysis included unfavorable factor related worsening of IBD activity and death. Results: 20 patients among 3756 ulcerative colitis (0.53%) and 2 patients among 3274 Crohn’s disease (0.06%) underwent SOT (22 patients from 7030 IBD patients, 0.31%). 17 patients (77.3%) had liver transplantation (LT) and 5 patients (22.7%) had kidney transplantation. The most common cause of LT was primary sclerosing cholangitis (n=11, 64.7%). 81.8% survival rate was observed after transplantation (n=18; median follow-up month, 50.3). After SOT, 31.8% (n=7) of the patients got worse IBD activity. The long duration until the first evaluation of IBD activity after SOT and low rate of SOT-related steroid use were significantly associated with the worsening of IBD activity (p=0.001 and p=0.009, respectively). The short interval between diagnosis of SOT causal disease and SOT was associated with death (p=0.033). 2 patients (9.1%) needed anti-TNF agents after SOT (response rate, 50%). 3 patients (13.6%) were diagnosed with malignancy (Burkitt lymphoma 1, colonic dysplasia 2). Conclusion: As the number of IBD patients increase in Asia, more cases of SOT in IBD patients are expected. Our results will provide informative data on how to manage patients who will receive SOT.