Moderators: Brandon Lawrence, MD; Harvey Smith, MD
Cell-based allografts are increasingly common alternatives to autograft and are marketed to contain osteoconductive, osteoinductive and osteogenic properties. Given the characteristics of these key properties for bone growth/formation, these products are being increasingly utilized with relatively little supporting scientific evidence. This symposium is designed to rigorously evaluate the evidence-based literature regarding these products, in addition to presenting background on the harvest and processing of mesenchymal stem cells. Faculty explore the importance of the progenitor cells, how they signal to the neighboring cells and how these cells are delivered (what carrier they are packaged in) will be the focus of this symposium. Presenters highlight what is important when deciding on the potential selection and use of a cell-based allograft.
The assembled faculty members are experts in the basic science of bone formation, and are clinically active surgeons. Three fifteen minute presentations focus on what products are currently available, the benefits and shortcomings of each product, what to focus on when choosing the currently available products and what would be ideal when developing new products. The final fifteen minutes are reserved for a panel discussion with the audience, moderators and speakers.
Upon completion of this session, participants should gain strategies to:
- Understand the basic science of the currently available products;
- Comprehend the relative strengths and weaknesses of currently available products;
- Contemplate how to improve cell-based allografts and critically evaluate future technology based on these design criteria.
Agenda
Intro/Basic Science of Bone Biology: Progenitor Cells and Their Signaling Needs
Carl Gregory, MD
Current State of Cell-based Allografts and How They Differ
Wellington Hsu, MD
How Do Cell-based Allografts Work?
Jason Savage, PhD
Factors to Consider in Deciding Whether to Utilize a Cell-based Allograft: Is There a Preferred Design Criteria?
Brandon Lawrence, MD
Where Are Cell Based Allografts Approved and Other Factors to Consider
Harvey Smith, MD
Panel Discussion/Questions and Answers
All Faculty