P099 - RESPONSE OF HEPATITIS B VACCINATION IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE; PROSPECTIVE OBSERVATIONAL STUDY IN KOREA
(Room Poster Hall)
19 Jan 18
5:30 PM
-
7:00 PM
Tracks:
Clinical and Research Challenges
Background & Aims: Testing for hepatitis B virus (HBV) serologic markers and appropriate vaccination are required in management of IBD patients. We evaluated the immnunogenicity for HBV in IBD patients and response of HBV vaccination those with non-immune state against HBV. Methods: From May 2014 to August 2016, patients older than 15-year old, diagnosed with IBD, and negative for anti-HBs antibody, anti-HBc antibody, and HBs antigen were prospectively included. Patients who had completed the three-time HBV vaccination received a single booster vaccination, while patients who had not completed vaccinations or had unclear memory received a full series of vaccination. Optimal level of response was defined as serum anti-HBs ≥10mlU/ml. Results: Among 73 patients (28 ulcerative colitis (UC), 45 Crohn’s disease (CD); 49 male, 24 female), 44 patients received the booster vaccination and 29 received the full series vaccination. Optimal response was obtained in 70.5% (53.8% UC, 77.4% CD, P = 0.155) in the booster group, and 89.7% (93.3% UC, 85.7% CD, P = 0.598) in the full vaccination group. Age younger than 26 years (odds ratio [OR], 5.20; 95% confidence interval [CI], 1.05-25.71; P = 0.043) and complete previous vaccination (OR, 0.17; 95% CI, 0.03-0.85; P = 0.031) were associated with optimal vaccine response. Complete previous vaccination history ((OR, 0.14; 95% CI, 0.02-0.82; P = 0.029) was only predictive factor for lower compliance of recommend vaccination. Conclusions: The response of HBV vaccination was lower in patients older than 26 years and those with complete previous vaccination. As the patients with complete previous vaccination also has poor compliance, serum HBV-titer should be checked more strictly, and full vaccination should be administered in the case with negative response for booster vaccination.