A New Dimension: How 3D Tissue Models Can Help to Advance Compound Development and De-Risking
(Room Orange Theater)
03 Feb 16
2:00 PM
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2:30 PM
Cell-based assays have become an inherent part of drug discovery and development to predict the in vivo response to chemicals, serving as a test system for target validation, primary and secondary screening, lead optimization and toxicological profiling. Advanced 3D tissue models provide a format, which reflects in vivo cellular functionality, either animal or human, as closely as possible, and gain momentum as a time and cost-saving means to improve drug de-risking. Engineering strategies for producing 3D models of various complexity and scalability will be discussed along with their exploitation to further improve the predictive power of in vitro assays